Biochemistry Laboratory for Advanced Screening and Therapeutics

Publications

Also on Google Scholar and ORCID.

2026

An RPEL-based FRET sensor for free monomeric actin
Fedoryshchak RO, Fons JM, Michrowska O, Renshaw M, Treisman R.
Journal of Cell Science, volume TBD, pages TBD

2025

PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin.
Fedoryshchak RO, El-Bouri K, Joshi D, Mouilleron S, Treisman R.
PP1/PNUTS phosphatase binds the restrictor complex and stimulates RNA Pol II transcription termination.
Erickson B, Fedoryshchak R, Fong N, Sheridan R, Larson KY, Saviola AJ, Mouilleron S, Hansen KC, Treisman R, Bentley DL.
Cell Reports 44(5), 115564 · doi:10.1016/j.celrep.2025.115564

2023

Discovery of lipid-mediated protein-protein interactions in living cells using metabolic labeling with photoactivatable clickable probes.
Fedoryshchak RO, Gorelik A, Shen M, Shchepinova MM, Pérez-Dorado I, Tate EW.
Chemical Science 14(9), 2419–2430 · doi:10.1039/d2sc06116c

2020

Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme.
Fedoryshchak RO, Přechová M, Butler AM, Lee R, O'Reilly N, Flynn HR, Snijders AP, Eder N, Ultanir S, Mouilleron S, Treisman R.
eLife 9, e61509 · doi:10.7554/eLife.61509
Wheat pathogen-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism.
Fedoryshchak RO, Ocasio CA, Strutton B, Mattocks J, Corran AJ, Tate EW.
RSC Chemical Biology 1(2), 68–78 · doi:10.1039/d0cb00020e

2018

Photoactivatable Myristic Acid Probes for UNC119-Cargo Interactions.
Kaiser N, Mejuch T, Fedoryshchak R, Janning P, Tate EW, Waldmann H.
ChemBioChem 20(2), 134–139 · doi:10.1002/cbic.201800406